@freedomrugya なわけない

2025年10月11日

@freedomrugya なわけない

— 銃とバッジを置いていけ＆ニチカン　共同運営アカウントをスタート (@kokosatoh)
Oct 11, 2025

from Twitter https://twitter.com/kokosatoh

October 11, 2025 at 03:36PM
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How to Stay Hydrated During an Anavar Cycle for Womenより:
2025年11月1日 9:03 AM
For extra average positive aspects (remember that not everybody needs extreme results), EQ is an excellent addition to an extended bulking cycle.
Frontloading EQ to get features transferring quicker
firstly of a cycle is a strategy some people swear by,
however an increase in side effects attributable to larger
doses makes this unrealistic for many people. Perhaps
EQ’s foremost mechanism of motion is its capacity to increase purple blood cell depend significantly.
All anabolic steroids will increase pink blood
cells to a level, however EQ is thought to be one of the powerful on this regard – hence its ability to transfer extra oxygen to the muscles and enhance endurance.
Equipoise has such a robust capability to boost red blood
cell depend that this will become a problem and is one thing
you should intently monitor whereas using this steroid.
Users often choose to stack it with other anabolic steroids to reinforce outcomes,
especially during chopping cycles.
The severity of those unwanted effects will depend upon the dose, length of the cycle,
genetics, and different steroids stacked with Dianabol.
We have had customers report strength gains of
25–30 lbs on their bench press (and different compound
exercises) in the course of the first week of administration (2).
Power gains on Dianabol are distinguished and could be skilled
within the early levels of a cycle.
We have discovered a high-sugar diet to be one of many main causes of
excessive cholesterol and blood stress in research and in patients; thus, lowering such consumption will cause reductions in LDL ranges.
Nonetheless, such health-compromised individuals ought to seek
the guidance of a physician, be informed concerning the side effects, and understand any potential authorized
ramifications before buying trenbolone. Therefore, people
with hypertension, high LDL (low-density lipoprotein) cholesterol, and hypogonadism should chorus from using tren, as it can exacerbate every of those circumstances.
For such people, trenbolone ought to be considered unsafe because of
the elevated risk of arteriosclerosis and myocardial infarction.
Lifestyle and genetic components can also affect the outcome of a trenbolone cycle.
As most will be using Primobolan during a slicing cycle this shouldn’t be too exhausting to do.
The Methenolone hormone carries a quantity of traits just like many other anabolic
steroids. This hormone will enhance protein synthesis (to a degree) and can have a moderate affect on rising red blood
cell rely. Nonetheless, the steroid carries three essential traits
that distinguish it more than anything else. This ensures a catabolic state is avoided and is also unbelievable for building lean tissue.
However, as talked about this steroid won’t pack on plenty
of measurement, hold that in mind. The hormone has additionally been shown to have a particularly
robust binding affinity for the androgen receptor.
Typical PCT protocols involve medicines like Clomid or Nolvadex, beginning 1-2 days after the
final dose. PCT is crucial after a Primobolan cycle to help restore pure
testosterone manufacturing and decrease potential hormonal imbalances.
In order to maintain healthy cholesterol, a ldl cholesterol friendly life-style
shall be necessary. It additionally means limiting easy sugars and saturated fats in your food regimen and together with plenty of omega fatty acids.
NPP has a short ester that releases shortly and offers quick outcomes however has to be injected rather more regularly than Nandrolone
Decanoate, which has a long-lasting ester.
Deca-durabolin is one compound that works wonderful with as little as 200mg; for therapeutic purposes, even 100mg does
the trick. Deca can be run for a very long time at a light
or lower dosage, and this makes it very appropriate for users who are on testosterone/hormone alternative remedy.
Whereas some underground labs have earned a popularity
amongst bodybuilders as being dependable and providing high-quality
Deca-Durabolin and other steroids, what they all have in frequent is
that they’re operating exterior of the legislation.
If you don’t like it, you’ll get it out of your system
fast and end up losing less money – with Deca-Durabolin, you’re looking at a minimum of 5 to six weeks of use earlier than you’ll be
able to consider your response. Customers notice that
joints just like the knees, shoulders, and elbows
really feel stronger and might help more weight, but common pains and aches are also relieved.
Even although Deca-Durabolin isn’t broadly considered a strong strength-boosting steroid, many users will nonetheless talk positively about energy features on a Deca cycle.
Additionally, individuals can have interaction in leisure techniques similar to meditation or deep respiratory to assist
promote relaxation and sleep. In addition, Trenbolone can also
disrupt the steadiness of hormones within the body, which may additional contribute to insomnia.
Hormones such as cortisol and adrenaline play a important role in regulating the
sleep-wake cycle, and disruptions to these hormones can result in insomnia.
It is necessary to notice that aggression attributable to
Trenbolone use may be harmful and even life-threatening
in some instances. If an individual experiences severe or uncontrollable aggression,
they want to search medical attention instantly.
Neurotransmitters are chemical compounds that transmit alerts between neurons within the mind, and so they play
an important function in regulating temper and feelings.
Trenbolone can disrupt the steadiness of neurotransmitters in the
brain, leading to temper swings and different mental health issues.
Nonetheless, when testosterone ranges are artificially elevated beyond normal ranges,
the dangers improve significantly. This sometimes entails a mixture of
particular person and group remedy to work by way of the psychological
dependence on steroids. Cognitive-behavioral remedy (CBT) is commonly used to assist people recognize
and change the thoughts and behaviors that led to their steroid use.
Remedy also helps them develop healthier ways to cope with challenges and increase vanity without having performance-enhancing medicine.
Recognizing anabolic steroid abuse often entails a mix of bodily, behavioral, and psychological signs.
The side effects of anabolic steroid abuse affect multiple areas of the physique.
This ranges from injecting into the incorrect spot or too often in the identical spot, inflicting ache, irritation, or an infection, to rather more severe issues like accidentally injecting right into a vein and putting your life in danger.
Trying for methods to make the method easier is sensible when you’re on this place.
One of the options we’ve includes backfilling
insulin syringes for steroid injections. In short, this method makes it each less painful
and extra convenient to administer your injections.
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PedsEliteより:
2025年11月1日 9:49 AM
The discovery of the anabolic properties of AAS resulted in AAS
use propagating into elite sports in the 1950s4.
It was not until the late Eighties that use gained ground amongst fitness center members
within the general inhabitants and is right now primarily used to enhance physique image and construct muscle tissue more easily5,6,7.
Current estimates recommend that about 2–3% of the inhabitants
have used AAS at some point5,6, however greater prevalence is seen amongst men6 and subpopulations
such as recreational weightlifters, bodybuilders, inmates8 and substance use patients9.
The concern of whether endogenous hyperandrogenism in female athletes because of certain medical problems imparts a “competitive edge” in sporting occasions stays unresolved.
The case of Ms. Semanya (and other athletes) has paved the finest way
for important discussions relating to the privacy
rights of female athletes in addition to equity in competitors in sporting occasions.
Though limited knowledge in women with endogenous hyperandrogenism suggests some beneficial effects on lean mass and muscle energy, extra research is required to totally perceive the impact of endogenous hyper-androgenism on athletic efficiency amongst elite female
athletes.
The anabolic androgenic results of anabolic steroids are primarily mediated through the androgen receptor (AR)-signaling motion. Androgen receptors
are present in all kinds of human tissues and organs, together with the skeletal muscle,
liver, prostate, central nervous system, and bone. The binding of
anabolic steroids to androgen receptors in these tissues
and organs results in a spread of results, including an increase in protein synthesis and muscle
mass, enhanced bone development and density, and a rise in red
blood cell manufacturing. The effects of anabolic-androgenic steroids (AASs) are mediated by way of the activation of androgen receptor (AR) signaling.
Due to the widespread expression of ARs in many various tissues, various
components of the body are concerned in the response to AASs [7].
This suggests that pubertal steroid exposure could produce long-lasting structural adjustments in sure
mind areas 148. Individuals who misuse anabolic steroids report extra anger than nonusers, as
nicely as more fights, verbal aggression, and violence toward
their vital others, typically known as “roid rage” 131,
132. One study means that the mood and behavioral results
seen throughout anabolic steroid misuse could end result
from secondary hormonal modifications 128. Some anabolic steroids are taken orally, others are injected intramuscularly sixty nine and nonetheless others
are supplied in gels or lotions which would
possibly be applied to the skin 70. Many users start with the oral form and then progress to injectable varieties,
for the rationale that latter causes less liver
damage seventy one. However, oral anabolic steroids clear more quickly from the body, usually making this the
preferred route for users concerned with drug testing seventy two.
With Out correct preparation for what you’ll be getting your self into with excessive
doses (we’re talking between 1000mg and
1500mg weekly), particularly concerning unwanted effects, think
long and onerous before jumping into this approach in your
first cycle. Reading about different people’s experiences with sure steroids on internet forums and social media
doesn’t put together you for what YOU will expertise with the same
steroid. So, by making use of one steroid at a time and getting a hold of which side effects you are vulnerable to and the way extreme they
are, you probably can slowly put collectively your personal safe and efficient stacks in the future.
For recurrent or persistent gynaecomastia, surgical treatment should be thought
of. Atrophy occurs because of multiple components
together with age, disease, and reductions in anabolic stimuli, together with unloading due to conditions similar to microgravity,
immobilization, or spinal wire injury (2, 21, 38, 40). These circumstances typically act through the ubiquitin-proteasome system, the Ca++-dependent calpains, and the lysosomal cathepsins pathway,
which together result in muscle protein breakdown and eventual
atrophy (3). Conditions of atrophy are marked by elevated
transcription and expression of genes corresponding to atrogin1
and MuRF-1 (39). Reductions in anabolic brokers similar to testosterone that
happen with age and lifestyle, often recognized as “andropause,” might closely contribute to decreased muscle mass and strength,
particularly in males (14, 42). Hypogonadal men have been reported
to exhibit three-fold increases in mortality and five-fold will increase within the threat of cancer-related demise (14).
Although reports suggest its potential protective effect
in opposition to gynecological cancers, the quality of the evidence remains insufficient for conclusions (Pinto et
al., 2023). Moreover, the Brazilian Society of Endocrinology and
Metabolism doesn’t recognize gestrinone implants as a therapy for endometriosis and
opposes their use as an anabolic agent. Many men who take anabolic steroids are infertile through the time of anabolic steroid use.
Because chronic anabolic steroid use suppresses spermatogenesis (sperm production), the testes shrink.
Many men who use anabolic steroids will also take human chorionic gonadotropin (hCG) to forestall testicular shrinkage.
Many males who use anabolic steroids report decreased libido or erectile perform.
As you will doubtless be utilizing either SERMs or AIs in your cycle to combat the side effects
of different compounds, these will help with Anadrol’s estrogenic effects.
Anavar comes with potential toxicity points to the liver, however a medium-length cycle should be manageable for most wholesome guys.
There’s some flexibility in Anavar dosing, with some guys using as low
as 30mg daily and going as much as 100mg in additional hardcore cycles.
Anavar will assist you to keep positive aspects
and work as a compound to keep your progress steady
with out delivering massive outcomes. If you’re going to
run an Anavar cycle, try my full Anavar (Oxandrolone)
cycle information. Anavar boosts the metabolism, and it is a core
principle if you’re going to cut fat.
All members provided written knowledgeable consent, which included particulars in regards to the
study’s function and justification. The abuse of AAS among competitive athletes is
growing at growing rates worldwide and becoming a trigger for concern among
the many medical professionals given the
susceptibility to adverse effects. The most regularly
reported opposed effects of AAS use amongst female athletes include hirsutism, alopecia,
deepening of the voice, clitoromegaly, menstrual disturbances and aggression (Strauss et al., 1985).
Previous research in non-athlete girls handled with supraphysiologic doses of androgens for a
selection of medical situations have reported voice modifications that included pitch fluctuations
and hoarseness (Baker, 1999; Damste, 1967; Talaat et al., 1987).
Curiously, although the above-mentioned masculinizing unwanted aspect effects
of AAS have been reported to be undesirable by the majority of feminine athletes, they nonetheless
considered AAS use acceptable as a end result of their ergogenic results (Strauss
et al., 1985). In addition to masculinizing adverse results, severe life-threatening adverse effects of AAS have also been reported among female athletes,
together with hepatic rupture, multi-organ failure and sudden dying (Nieschlag and Vorona, 2015a; Povzun, 2016; Thiblin et al., 2009).
Regardless Of the well-documented effects of testosterone and its artificial derivatives—collectively termed anabolic androgenic steroids
(AASs)—on the musculoskeletal system, the therapeutic use of those brokers has obtained limited investigation within the area of orthopaedic surgery.
Some imagine very lengthy cycles starting from three to 9 months can convey everlasting features.
Testosterone Enanthate (Cypionate) is the compound mostly used in an extended cycle.
As anticipated, the heightened threat of significant unwanted side effects
of those extra-long steroid cycles makes it a strategy that
shouldn’t be taken frivolously. In the Netherlands, as
in most other European international locations, anabolic steroids, corresponding to testosterone, can solely be obtained via a pharmacy with a doctor’s prescription. Since most doctors aren’t willing to prescribe steroids for performance
and image-enhancing purposes, most steroid abusers are depending on unlawful suppliers.
On the web, many web sites market anabolic steroids and offer shipment all round the
world. In our experience, most customers of AAS use the web as a source of knowledge, but retrieve products
via native dealers.
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plan muscléより:
2025年11月1日 10:15 AM
LH and FSH, in turn, bind to their cognate receptors on the Leydig cells and Sertoli cells of
the testis, respectively. LH stimulates testosterone production and,
at the side of FSH, regulates spermatogenesis.
Testosterone, and its estrogenic metabolite estradiol, exert negative suggestions on the hypothalamus
and pituitary to suppress their own synthesis (173, 174). Estradiol in particular is very potent
at suppressing gonadotropin secretion as, on a molar foundation,
it is estimated to be 200-fold more potent than testosterone
in doing so (175). Consequently, exogenously administered AAS may even exert adverse feedback, thereby suppressing testicular testosterone
manufacturing and spermatogenesis.
Human physiology differs from individual to individual, no matter how
correct a calculator is, it’ll never be one hundred pc accurate.
Effectively managing the energetic dose of a steroid cycle means understanding how each compound is released and metabolized in the body over time.
The rate at which a steroid’s lively dose declines is decided by its half-life, and this decay may
be modeled mathematically to help users plan their cycles more precisely.
Relying on the half-life of a steroid to determine your drug test threat is, subsequently, a great mistake.
Solely probably the most fundamental of drug testing will look for the steroid hormone itself somewhat than its metabolites.
There could be lots of misunderstanding
about how drug testing for steroids and performance-enhancing
drugs works. Many assume it’s a easy matter
of supplying a urine (or blood) sample, having the pattern despatched to a lab, and being put via a machine that magically detects each
substance. Fortunately for athletes and bodybuilders, but not so fortuitously for anti-doping authorities,
it is removed from such a straightforward and basic process.
This testosterone ester is a long-acting steroid with a
half-life of 8-12 days. This means it’s slow-acting compared to another testosterone esters,
and it could take 4 or extra weeks until you
start seeing noticeable enhancements in power, typically so lengthy as six
weeks. Even a low dose of testosterone can provide a
strong increase to efficiency and gains, and if you’re starting, you might need
to check the waters with the bottom, most effective dosage.
These so-called gentle cycles of round 250mg per week nonetheless
provide advantages whereas lowering the impression of unwanted side effects.
A typical cycle of this kind would come with Testosterone Cypionate at 500mg weekly and Deca at 400mg weekly for 12 weeks.
For those people who find themselves in search of large muscle mass achieve, they’ll combine two or extra medication per cycle.
What we’ve to remember when it comes to females using anabolic steroids is that you are introducing male androgen hormones into your physique at ranges a lot larger than would ever be
produced naturally. But unlike males who will gain little muscle with these “milder” steroids, women will discover that these are more than powerful enough to advertise good muscle
features, along with fat loss and performance benefits.
One common strategy to cope with this is to incorporate a
fast-acting steroid initially of the cycle (usually
an oral steroid), which acts as the first anabolic agent,
whereas your slower steroids take time to kick in.
Medically, it’s used by men who have low testosterone and infertility.
In addition, you have to take correct rest
time between two cycles that can assist you get well
shortly and enhance your well being. People who’ve any extreme
ailments or current surgery, they want to strictly keep
away from this drug. The half-life of a steroid is a very different idea to detection time.
Whereas the half-life does influence detection time to an extent, you can’t rely
on a steroid’s half-life to estimate just how lengthy that steroid would possibly be capable of be detected by
way of drug testing.
This class of drugs inhibits the enzyme PDE5 which breaks down cGMP – the second messenger molecule answerable for conveying
the sign of the cavernous nerve to induce an erection (195).
PDE5 inhibitors are the mainstay drug in erectile dysfunction remedy
and are usually tolerated nicely, providing passable results.
Side effects embrace headache, flushing, dyspepsia, nasal congestion, dizziness, transient irregular vision and cyanopsia (specific
to sildenafil), and again pain and myalgia (specific to tadalafil) (196).
Whereas these medication are generally already acquired by AAS customers from the
black market, they could be prescribed to patients affected
by erectile dysfunction which is either organic or psychogenic
in nature.
Testosterone levels lower again after the agents are discontinued,
implying that they don’t solve the underlying reason for hypogonadism.
As such, it stays to be seen whether they present efficacy within the case of AAS-induced hypogonadism, as
PCT is normally performed for a quantity of weeks.
In the HAARLEM examine, testosterone levels have been comparable 3 months after cessation of
AAS use in those that did and didn’t carry out PCT,
however a small beneficial effect inside this time frame could not be excluded (46).
Finally, hCG immediately stimulates the testes to provide testosterone by binding
to the luteinizing hormone/choriogonadotropin receptor (LHCGR) which it shares
with LH. This could result in continued suppression of LH and FSH ranges when employed as PCT,
but is assumed by AAS customers to assist in restoration of testicular perform.
A primary Testosterone Cypionate cycle that uses no other AAS is so simple as attainable.
It’s a cycle that must be the first port of call for any brand-new steroid user – as a result of Testosterone Cypionate is
the safest steroid we are ready to use by far. Nevertheless, even experienced customers will continue running Testosterone Cypionate cycles regularly.
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