石丸某氏の論法、恥を知れ、恥を、、、と怒鳴って、その後、市民がそう思ってる。と付け加えれば問題ないわけ。 https://t.co/Qje3dBFaom

2025年9月13日

石丸某氏の論法、
恥を知れ、恥を、、、と怒鳴って、その後、市民がそう思ってる。と付け加えれば問題ないわけ。 https://t.co/Qje3dBFaom

— 銃とバッジを置いていけ＆ニチカン　共同運営アカウントをスタート (@kokosatoh)
Sep 12, 2025

from Twitter https://twitter.com/kokosatoh

September 13, 2025 at 04:14AM
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一般ニュース解説

@kakimotogenki これな、SNSで炎上するとかなりまずくなりそうだ。

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https://www.giveawayoftheday.comより:
2025年10月27日 10:56 PM
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Female Bodybuilder Steroid Useより:
2025年11月1日 9:48 AM
As AAS use is seen negatively, a non-judgmental healthy and
trusting physician–patient relationship is important within the administration. The patient should be counselled to stop all AAS as nicely as
any self-administered ancillary drugs and supplements.
For patients with histopathological abnormalities (namely,
sperm maturation arrest), IVF-ICSI has been used but there is no printed data
confirming the success.
The use of picture and performance enhancing drugs is something that has been around for many years, most noticeably
on the planet of sport. Think About reading scientific research,
speaking with healthcare professionals, and fascinating with communities where individuals share their experiences.
By educating your self, you’ll be able to better understand the dangers involved and discover different methods to
achieve your fitness goals without compromising
your long-term health. How lengthy it takes for
steroids to have an result on sperm varies, but results may be seen relatively quickly, emphasizing the significance of warning
regardless of dosage. Growing sperm rely after steroids includes sensible
expectations, as the restoration process may be
sluggish and incomplete. Artificially increasing blood testosterone to ultra-high ranges causes
the body to construct extra muscle fibres, but it also tells
the brain that the body is producing an excessive amount
of testosterone and it makes an attempt to appropriate
it by shutting down its manufacturing in the testicles.
The management of testosterone misuse or abuse requires a disciplined approach from cessation methods to medical interventions to revive fertility.
The authors speculated that this might be because of a differential exercise-induced
expression of endometrial proteins concerned in its receptivity [28].
One Other study reported higher pregnancy charges among girls having more active life the year
before in-vitro fertilization compared to sedentary ones [29].
Curiously, voluntary exercise appears to improve
oocyte high quality in obese murine model [30].
In detail, it increased oocytes β-oxidation enzyme hydroxyacyl-coenzyme A dehydrogenase ranges in mice which
have been fed with a high-fat food regimen, thus reversing lipid accumulation in germinal vesicle stage oocyte [30].
Regardless Of these deleterious effects, sufferers are sometimes
not properly counseled earlier than the initiation of AAS.
Research report that fewer than half of sufferers were
aware of the consequences of AAS on fertility [6]. Alarmingly, physicians prescribing the medicine are additionally not
absolutely conscious of the potential impression on fertility.
The privateness and confidentiality of particular person patient knowledge had been maintained all
through the examine period and post‐study.
•All patients underwent a compulsory 3‐month statement earlier than beginning treatment drugs.
Simply to note, AASs are very completely different to corticosteroids which
you would possibly have had prescribed out of your GP.
While patients in our collection were extensively endorsed that AAS use can lead to
azoospermia, it is potential oligozoospermic sufferers had been in a place to provide a semen evaluation appropriate for IVF/ICSI and
elected to resume AAS remedy. Notably, there’s a lack of information on harm reduction (Anawalt,
2019; Bonnecaze et al., 2021), which are methods that purpose
to reduce and cease using AAS in the long term. To date, current proof demonstrates the helpful results of harm reduction by way of academic approaches and help
to both customers and medical docs (Eu et al., 2023).
Researchers in Australia have educated medical doctors from a number
of clinics and hospitals serving AAS customers within the country on harm reduction methods that may
be implemented throughout a medical consultation (Eu et al., 2023).
AAS induces intracellular androgenic actions that stimulate gene cascades important for
mobile homeostasis. Additionally, AAS administration is linked to transient elevations
in serum enzymes, such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT), which point out hepatocellular harm (Hartgens and Kuipers, 2004, Petrovic et al., 2022).
The use of nandrolone decanoate in rats for six- and
twelve weeks elevated AST and ALT, regardless of the dose and period of use (Salem and Alnahdi,
2020). The overload of AAS impairs primary liver functions, resulting in hepatotoxicity (Marocolo
et al., 2018). AAS presence in liver tissue will increase oxidative stress and mitochondrial oxidation, generating an imbalance between free radical production and
the integrity of the mobile framework, ultimately inflicting liver damage (Arazi et al., 2017).
Antioxidants have proven protective results in opposition to AAS-induced hepatotoxicity (Frankenfeld et al., 2014).
Stanozolol, a synthetic spinoff of testosterone (Dodge and Hoagland, 2011),
is a white crystalline substance soluble in water, alcohol, chloroform,
and dimethylformamide (Lemma et al., 2017).
They’re manufactured medication that carefully resemble cortisol, a hormone that your adrenal glands produce naturally.
The fact is steroids have caused extra severe unwanted
effects on women than they do men. There other alternate options together with authorized steroids for girls that offer comparable
advantages with out the unwanted effects. General, 774 patients
who presented with a confirmed historical past of AAS intake
have been screened.
Nonetheless, no information have been obtained on the share of males attempting to
attain a pregnancy during or following the research.
Maintenance of spermatogenesis and intratesticular testosterone
levels has also been reported with HCG and AIs within the presence of exogenous testosterone administration within the hormone replacement remedy population (7,19,20).
These research recommend a attainable mechanism for the
preserved fertility rates among our cohort of men. In the current review, we discovered that the
motivating components for beginning AAS have
been muscle development, elevated libido, improved sexual efficiency, virility and alleviated ageing process.
For well being care providers, it underscores the necessity for a nuanced strategy to treating sufferers who have a historical past of AAS use.
General suggestions might not suffice, and personalised therapy plans could be more practical.
The study population included in our evaluate is consultant of the current real-world epidemic of AAS
use in society wherein athletes in addition to novice people are
taking many medicine in supraphysiologic doses with out medical supervision. Although
many of the research report normalisation of the hormonal milieu by 1 year of AAS abstinence,
Coxon[42] reported a case of hypogonadism persisting 3 years after stopping AAS.
Equally, Boregowda et al.[41] reported a 40-year-old male who developed prolonged and irreversible gonadal failure and infertility after AAS
use. This affected person introduced with erectile dysfunction and secondary gonadal failure in the
type of low ranges of FSH, LH and TT 2 years after stopping AAS.
Flanagan and Lehtihet[17] reported dysfunction of hypothalamo–pituitary–gonadal axis (HPG) within the type
of attenuated response to gonadotrophic releasing hormone and
human chorionic gonadotropin (hCG) stimulation tests despite an AAS washout interval
of 7 months. Urhausen et al.[24] additionally reported restoration of HPG axis hormones over 1 yr
of stopping AAS.
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