【韓国】ＷＢＣで大谷翔平に「故意死球」発言の高佑錫が１球も投げずにパドレスから放出される(東スポWEB)

2024年5月11日

RT @qsfkbwIhuWLhnjI: 【韓国】ＷＢＣで大谷翔平に「故意死球」発言の高佑錫が１球も投げずにパドレスから放出される(東スポWEB)

https://t.co/XyzJSuRs5u

— 銃とバッジを置いていけ＆ニチカン　共同運営アカウントをスタート (@kokosatoh)
May 5, 2024

[INOUE1]

だからこいつら部族はスポーツやらせる前に道徳だよ🤣

— 九里凛 (@hino_moto1) May 4, 2024

ＷＢＣで大谷翔平に「故意死球」発言の高佑錫が１球も投げずにパドレスから放出される …。

大谷に対し「投げるところがなくなったら当たっても痛くないところにぶつけようか」

野球の神様に愛されている選手を敵に回すと神様のバチが当たります。https://t.co/896sbytIop

— ピ口.yas (@uVCyzHfmTeGkvxJ) May 5, 2024

スポーツ解説,一般ニュース解説

癒されます

野球で死亡【アクシデント】頭部にゴロ直撃のDeNA宮崎敏郎、意識しっかり出血なし「頭部打撲」三浦監督 https://t.co/lAFev46liy

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streamifyr.comより:
2025年10月27日 3:08 AM
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gitea.zerova.comより:
2025年10月27日 9:48 AM
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dianabol cycle before afterより:
2025年10月30日 3:59 AM
Ipamorelin and sermorelin are two synthetic peptides
that have become popular among athletes, bodybuilders, and individuals seeking anti-aging therapies because they stimulate the release
of human growth hormone (HGH) from the pituitary gland. Although both drugs
ultimately increase circulating HGH levels, their chemical structures, mechanisms
of action, dosing schedules, and side-effect profiles differ significantly.
Understanding these differences is essential for determining which peptide may be more suitable for a particular individual’s goals and health
status.
Introduction to Ipamorelin and Sermorelin
Ipamorelin (also known as Phe-Glu-D-Ala-Lys-Leu)
is a pentapeptide that selectively binds to the ghrelin receptor,
also called the growth hormone secretagogue receptor 2.
It mimics the natural hormone ghrelin but with much higher potency and selectivity for
GH release while sparing other ghrelin-mediated effects such
as appetite stimulation. Ipamorelin is usually administered by subcutaneous injection once or twice daily, with doses ranging from 200 to 400 micrograms
per kilogram of body weight. Its pharmacokinetic profile allows
it to produce a rapid but short-lasting spike
in HGH that returns to baseline within two to three hours.
Sermorelin (also known as GHRH analogue) is a heptapeptide derived from the
naturally occurring growth hormone releasing hormone (GHRH).
It binds directly to the pituitary receptor for GHRH, causing a more physiologic release of HGH.
Sermorelin is typically injected once nightly
before sleep because it has a longer half-life than ipamorelin and produces a sustained overnight surge in GH levels.
Standard doses are usually between 0.2 and 0.5 milligrams per kilogram.
Understanding Human Growth Hormone (HGH)
Human growth hormone is produced by the anterior pituitary gland
and plays a critical role in regulating body composition, muscle and bone growth, metabolism of fats and sugars, and overall cellular repair.
The release of HGH follows a pulsatile pattern that peaks during deep sleep and declines gradually with age.
Low endogenous GH can lead to decreased lean mass, increased fat deposition, reduced exercise performance,
slower wound healing, and diminished quality of life.
Both ipamorelin and sermorelin aim to restore or enhance this
natural rhythm by stimulating the pituitary gland through
different receptors. While the ultimate result is increased circulating
HGH, the pathways involved determine not only efficacy but also
side-effect profiles.
Ipamorelin vs. Sermorelin: Which is Better for You?
The choice between ipamorelin and sermorelin depends on several factors
including desired timing of hormone release, tolerance for injections,
potential side effects, cost, and personal health goals.
Timing of Hormone Surge
– Ipamorelin produces a rapid spike in HGH shortly after injection, making
it useful for athletes who want to align the surge with training sessions or pre-meal periods.
The effect is short-lived, so additional injections may be required throughout the day if continuous stimulation is
desired.
– Sermorelin’s overnight profile aligns closely with natural sleep patterns.
For individuals who prefer a single daily dose and aim for sustained GH levels during rest, sermorelin can be more convenient.
Appetite and Metabolic Effects
– Because ipamorelin selectively activates the ghrelin receptor for
growth hormone release while sparing appetite pathways, it
is less likely to increase hunger or cause significant weight gain. Some
users report mild stomach discomfort but not increased caloric
intake.
– Sermorelin, being a GHRH analogue, does not directly affect appetite.
However, because its action mimics natural GH patterns
more closely, it may indirectly influence metabolic rate
over time.
Side-Effect Profile
– Ipamorelin is generally well tolerated. The most
frequently reported side effects are mild injection site reactions such as redness or swelling,
transient headaches, and occasional feelings of fatigue immediately after
the surge. Because it does not stimulate other ghrelin receptors, significant fluid retention or edema is rare.
– Sermorelin can cause similar injection-site discomfort but also has a higher incidence
of transient water retention and mild edema in some users.
Rarely, patients experience increased insulin resistance or glucose intolerance, especially when combined with other anabolic agents.
Long-Term Safety Considerations
– Both peptides are considered safe when used within recommended dosing ranges.
However, ipamorelin’s selective action may pose a lower risk of
long-term hormonal imbalance because it does
not interfere extensively with other pituitary axes.
– Sermorelin, by stimulating the entire GHRH receptor pathway, could theoretically affect downstream hormones such as prolactin or thyroid-stimulating hormone if
used at high doses or over prolonged periods. Routine monitoring
of blood hormone levels is advised for long-term users.
Cost and Accessibility
– Ipamorelin peptides are typically available in smaller vial
sizes (e.g., 1 mg per vial) which can be more cost-effective for intermittent use.
– Sermorelin tends to come in larger doses (0.2–0.5 mg), making it a bit more expensive per milligram but offering the convenience of once-daily
dosing.
Compatibility with Other Therapies
– If an individual is already using anabolic steroids, testosterone boosters, or other peptide therapies
such as BPC-157 or TB-500, ipamorelin’s short action may be easier to integrate without overlapping peaks that could overstimulate the pituitary gland.
– Sermorelin’s prolonged release might lead to cumulative GH exposure when combined with other agents,
potentially increasing side-effect risk unless carefully monitored.
Practical Tips for Minimizing Side Effects
Use a fine-gauge needle and rotate injection sites
to reduce local irritation.
Dilute peptides in sterile saline or water as recommended; avoid using tap water.
Maintain proper hydration before and after injections; this helps mitigate any mild edema.
Keep a detailed log of dosage, timing, diet,
and any symptoms. If headaches, dizziness, or unusual fatigue appear, reduce the dose
or take a break for a few days.
For those concerned about blood glucose changes, check
fasting glucose or HbA1c periodically while on therapy.
Monitoring and Follow-Up
Because both ipamorelin and sermorelin affect the endocrine system,
regular follow-up with an endocrinologist or qualified
healthcare provider is prudent. Blood tests to assess serum HGH, insulin-like growth factor 1
(IGF-1), thyroid function, prolactin, and glucose metabolism can help detect any
unintended hormonal shifts early.
Conclusion
Choosing between ipamorelin and sermorelin involves balancing the timing
of hormone release, potential side effects, convenience, and
cost. Ipamorelin offers a rapid, short-lasting GH surge
with minimal appetite or fluid retention issues,
making it attractive for athletes seeking targeted performance boosts.
Sermorelin provides a more physiologic overnight pattern that aligns well with natural sleep cycles but may carry a
slightly higher risk of transient edema
and glucose disturbances if not monitored. Ultimately, the
better option depends on individual health goals, tolerance for injections,
lifestyle preferences, and willingness to engage in regular monitoring to ensure safety and
efficacy.
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PedsEliteより:
2025年11月1日 7:34 AM
We see these compounds usually used in the off-season (winter period), when bodybuilders eat in a
calorie surplus. Many things can influence how properly your androgen receptors regulate and use hormones, similar to medication, previous
steroid use, and genetics. Artificial steroids can supply medical advantages
when used responsibly and underneath proper medical supervision. Nonetheless, their misuse in athletics and
bodybuilding can have extreme health and authorized ramifications.
As they’ve been typically called”steroids,” individuals frequently imagine these are precisely the exact equivalent
task as anabolic steroids, which can be utilized to boost physical and energy
performance. But if they talk about some molecular parts, the
two really are fairly numerous. Amy Eichner, PhD, U.S.
Anti-Doping Agency’s Special Advisor on Drug Reference and Supplements, explains
5 things you need to find out about steroids, including the distinction between corticosteroids and anabolic steroids.
It must be famous that DHT isn’t thought to contribute
to the muscle-building effects of testosterone. DHT levels are (very) low in skeletal muscle because it doesn’t significantly
specific the enzyme. DHT additionally seems to be damaged down in skeletal
muscle by inactivation to 3α-androstanediol by the enzyme 3α-hydroxysteroid-dehydrogenase (20,
21). Indeed, changes in fat-free mass in response to graded doses
of testosterone are unaffected by DHT suppression with the potent 5α-reductase inhibitor dutasteride (22).
The conversion of testosterone to DHT reveals saturable Michaelis-Menten kinetics with an estimated in vivo
Km value of three.35 nM (23).
The main difference between testosterone medicines and steroids is that TRT is legal.
It have to be prescribed by a medical doctor and entails
the use of federally-controlled medicine that are administered
in physiological doses. AAS are presently
unlawful performance-enhancing drugs used to improve power,
speed, endurance, and aesthetics. The results of these medication are dose-dependent, so larger doses lead to larger and quicker results.
This evaluation due to this fact provides a comprehensive overview
of this class of hormones’ basic pharmacology and side effects.
It stays debatable whether or not physicians ought to medically target unwanted effects of AAS use.
Obviously, discontinuing AAS could be the preferred answer for just about every facet effect.
Anadrol (oxymetholone) is thought to be some of the potent bulking steroids, generating slightly more weight accumulation than Dianabol in our
expertise. D-Bal is an optimum compound for individuals desirous to add notable muscle mass with out shutting down their testosterone production. Endogenous
testosterone ranges usually normalize a number of weeks following cycle cessation. Testosterone is androgenic; thus, we generally
observe prostatitis (inflammation of the prostate), acne vulgaris, and
male sample baldness in sufferers. Some customers could turn into aggressive
or combative, consider things that aren’t true (delusions), or have excessive emotions of mistrust or
concern (paranoia). And individuals who use steroids
additionally seem like at greater risk for utilizing other medication, such as alcohol or cocaine, typically
to counteract some of the negative results of steroids.
Medicine commonly known as “steroids” are categorized as corticosteroidsor anabolic (or anabolic-androgenic) steroids.
These substances may help people obtain their desired body composition and enhance their
athletic efficiency. On the other hand, testosterone
alternative therapy (TRT) is a typical medical therapy for people with low testosterone levels.
It can enhance vitality ranges, mood, sexual function, and general quality of
life for those experiencing testosterone deficiency.
Anabolic steroids are artificial substances that mimic testosterone, used to enhance muscle development and
performance.
Different unwanted effects are muscle weak spot, eye problems (including cataracts), and a better threat of diabetes.
Ergogenic makes use of for AAS in sports activities, racing, and bodybuilding as performance-enhancing medication are controversial because of their antagonistic results and
the potential to gain benefit in physical competitions.
Their use is referred to as doping and banned by most major sporting our bodies.
Primobolan is one other steroid derived from DHT,
which is relatively female-friendly at decrease doses.
They ought to allow you as a female person to keep away from androgenic unwanted effects of a virilizing nature.
Still, as at all times, you should be open to experimenting with different dosages and decreasing it if required – depending on your tolerance of
unwanted effects. It’s undoubtedly the preferred anabolic steroid with female athletes
of different types.
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