怒りの矛先が小林製薬に向いているが、お門違いも甚だしい。証拠もないのに突然クロ扱いした厚労省とマスコミのせい。紅麹原料の流通先は３万３０００社か…こだわりソーセージに使用の食品メーカー「売り上げの３分の１失った」

2024年4月9日

RT @onjee6: 怒りの矛先が小林製薬に向いているが、お門違いも甚だしい。証拠もないのに突然クロ扱いした厚労省とマスコミのせい。

紅麹原料の流通先は３万３０００社か…こだわりソーセージに使用の食品メーカー「売り上げの３分の１失った」
https://t.co/IUhAg…

— 銃とバッジを置いていけ＆ニチカン　共同運営アカウントをスタート (@kokosatoh)
Apr 6, 2024

[INOUE2]

悪いのは紅麹全般を悪者に仕立て上げたマスゴミであって小林製薬じゃないでしょ。コロナ禍で感染者全般を悪者にした時とまるで一緒。何回繰り返すの？バカなの？

紅麹原料の流通先は３万３０００社か…こだわりソーセージに使用の食品メーカー「売り上げの３分の１失った」 https://t.co/hwTLPUC9GZ

— あーぁ (@sxzBST) April 6, 2024

こういうのを本当の「風評被害」と言うんじゃないのかね。
紅麹が原因だと言い切った人は、もしそうでなかった場合、どうやって責任を取るのかね。https://t.co/t1aAJ3xwWV

— 西尾政孝 (@masatakatze) April 6, 2024

小林製薬を悪者にしたいかのような報道ですが、３万３０００社に流通している紅麹で今まで何の問題も起こっていないことを冷静に受け止めるべきです。

問題なくても自主回収を求める社会、コロナ禍での自粛もそうですが、マスコミが作る圧力社会、もうやめませんか？ https://t.co/33OIRFcH7C

— 稲垣昭義 (@dream21ai) April 6, 2024

楽天モバイル最強プラン 3GBまで ⇒ 税込1,078円/月 ※通話料等別無制限 ⇒ 税込3,278円/月 ※通話料等別

一般ニュース解説

真面目に働いて税金納めてるのが馬鹿らしくなってきたな…という投稿が話題に。 https://t.co/lyVAv5ia7O

コメント一覧

ophiuchus.wikiより:
2025年10月27日 3:05 PM
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Stratégies nutritionnelles pour le gain musculaire pendant le jeûneより:
2025年11月1日 8:19 AM
In this case a loss of libido as a end result of testosterone
deficiency usually underlies the erectile dysfunction. Not
uncommonly in this time interval, dissatisfaction with the intercourse, frustration of the sexual relationship with the mattress partner(s),
and loss of self-confidence could result in perpetuation of erectile dysfunction even when testosterone ranges get well.
The mechanism for that is unclear, but, given that estradiol, independently of testosterone, additionally plays a job
in regulating erectile perform (194), it’d involve an imbalance between androgenic and estrogenic action. Erectile dysfunction may be a consequence
of psychological factors, as libido may rise sharply in an AAS consumer during the cycle and sometimes hinder a healthy and mutual
sexual relationship. Lab workup was obtained which included a complete blood count (CBC), creatinine, electrolyte
panel, hemoglobin A1C, whole prostate-specific antigen (PSA), lipid panel,
and a basic liver function panel. The patient’s hemoglobin was elevated
at 18.0 g/dl however his CBC was in any other case unremarkable.
Electrolyte panel together with liver enzymes and other liver perform checks had been normal, as was the
patient’s PSA.
This might doubtless end result within the early onset of situations generally noticed
in long-term users, such as dyslipidaemia, hypertension, erectile dysfunction, and cognitive impairment [3, 44, 45].
Concerning the shortage of experience with power training,
a untimely use of anabolic steroids might enhance the chance of injuries on tendons and muscle ligaments abruptly required to support the workload
of drug-enhanced muscular tissues [46,forty seven,48].
The most severe complication of anabolic steroid use is the event of hepatic
tumors, both adenoma or hepatocellular carcinoma. The hepatic tumors arise in patients on long run androgenic steroids,
usually throughout therapy of aplastic anemia or hypogonadism, but often in athletes or body builders utilizing
anabolic steroids illicitly. Tumors are sometimes discovered after
5 to fifteen years of use, however onset within 2 years of beginning therapy
with testosterone esters has been described.
Many of the case reviews have occurred in sufferers with other threat
elements for cancer, similar to Fanconi’s syndrome, iron overload or persistent hepatitis C (from
blood transfusions).
These paperwork deal with the systematic state-sponsored programme
of doping of athletes and included scientific
stories, doctoral theses and a hand-written protocol book giving
the occasions and dosage of administration of anabolic steroids to athletes.
A Number Of thousand athletes were handled with anabolic steroids yearly, together with adolescents of each sex.
Explicit emphasis was positioned on the administration of
anabolic steroids to ladies and adolescent women, regardless
of the virilizing results, due to the fast features in sporting efficiency.
It is essential to notice that the GDR scientists established (to themselves) that ‘androgenic initiation’
has everlasting results in women and girls, where will increase in energy and performance
do not return to pretreatment values after the drug is withdrawn.
A latest British army report describes AAS use by 4% of navy trainees
to assist physical efficiency and recovery, representing a novel AAS person (Casey, Hughes, Izard, & Greeves,
2014). Yet these numbers might underrepresent what clinicians encounter as solely half of AAS customers admit to
prior AAS use when interviewed by a physician (Pope,
Kanayama, Ionescu-Pioggia, & Hudson, 2004). Third, one should
enable for the unknown number of AAS users who die prematurely – as advised, for example, by the examine of Parssinen and colleagues (Parssinen et
al., 2000), which found more than 4 instances as many deaths amongst former probably AAS
users as in an age-matched male inhabitants.
Of course, some AAS customers in the inhabitants are well over age
45 – especially men who competed in bodybuilding competitions or Olympic occasions in the Nineteen Sixties
and 70s, such because the Swedish pattern described above (Lindqvist et al., 2007).
Nonetheless our expertise from interviews of quite a few older weightlifters, together with revealed stories within the media, suggests that the
doses of AAS used in the Sixties and 70s were usually a
lot decrease than those used today. It also needs to be remembered that almost all AAS
users previous to 1980 had been competitive athletes, presumably trying to optimize their well being
and efficiency, and barely utilizing different illicit drugs for leisure functions.
For instance, among the older athletes within the Swedish sample, greater than 80% reported that that they had
never used any leisure illicit medication of their lives.
By comparison, most modern AAS customers usually are not
aggressive athletes, and heaps of use giant amounts of other illicit recreational drugs (Kanayama et al.,
2003b) and different probably hazardous body-image drugs (Kanayama et al., 2001b;
Parkinson and Evans, 2006). Thus with advancing age, the outcomes of those people may be fairly different from the outcomes of
older elite athletes.
Furthermore, one other study demonstrated that supraphysiological doses of AASs impair the useful
results of physical activity on hippocampal
cell proliferation and apoptotic signaling [41].
Endurance exercise improves the redox system stability by stabilizing the mitochondrial membrane, resulting in a discount of apoptotic results of ND in neural
cells [25]. Flowchart of positive and negative effects of anabolic-androgenic steroid (AAS)
administration. Extended and high doses of
testosterone and his derivatives result in critical consequences in all physique tissues and
organs. Adverse effects are quite common in steroid customers,
with some affecting over 10% of users.
Very Important indicators, including heart rate and blood strain, and basic chemistries, similar to sodium, potassium, hemoglobin, hematocrit, BUN (blood urea nitrogen), creatinine, hepatic, and lipid profiles,
must be monitored rigorously. Monitoring these parameters will help the clinician to find out drug selection, remedy dose, and
period, and can assist to alert the prescriber to doubtlessly critical
opposed effects that necessitate the discontinuation of remedy.
Abuse of anabolic steroids, nonetheless, can lead to significant harm to the body.
In people, abuse can lead to coronary coronary heart disease, sexual and reproductive disorders, immunodeficiencies, liver injury, stunted progress,
aggressive behaviour, susceptibility to connective
tissue injury, and (in females) irreversible masculinization.
Understanding your body’s estrogenic response is essential in optimizing the effectiveness of
the steroid you select. This is the primary study performed among Palestinian physical training college students on the utilization of AASs.
Regardless Of being conscious of the favorable benefits of AAS on muscle
progress and strength, nearly all of the survey members indicated a considerable lack of knowledge
on the potential detrimental side effects
of AAS on various body systems. This information could be useful in directing
efforts and modifying policies to handle the difficulty of AAS misuse within the healthcare system.
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PedsEliteより:
2025年11月1日 4:02 PM
TE considerably increased the number of rat L6 cells expressing MYOG and considerably increased MYOG expression ranges in grownup human males as in comparison with a placebo (10, 14, 20).
Nonetheless, TE caused no vital changes in MyoD or MSTN mRNA abundances in grownup human males (20).
Between-treatment effects of MSTN had been 64% lower with TE administration in rats compared to a sham control (5).
TE considerably stimulated IGF1 and MSTN expression in each rats and older male humans,
with IGF1 expression reaching values fivefold higher in a traditional condition of 10-month-old
male fisher 344xF1 Brown Norway rats in comparison with
orchiectomized (ORX) groups (7, 14, 42). Nevertheless, TE didn’t significantly affect the
total concentrations of MHC isotype mRNA in 18–35-year-old human males relative to different
groups (35).
Chronic AAS use must be considered when a muscular man presents with infertility
or onset of gynecomastia, or a hirsute, muscular girl stories amenorrhea.
Serum high-density ldl cholesterol and intercourse hormone–binding globulin concentrations are often very
low. The most useful of the generally available exams are
measurement of serum testosterone, follicle stimulating hormone (FSH),
and LH concentrations. As A Outcome Of exogenous
testosterone, nontestosterone AASs, or hCG
suppress circulating gonadotropin concentrations, measurement of serum testosterone, FSH, and
LH concentrations are useful for figuring out the probability of AAS
use (Table 2).
Tamoxifen and letrozole inhibit estradiol and androgens results on telomerase exercise which is not affected by
flutamide (an androgen receptor antagonist) administration [46].
Alterations in telomerase activity are at the foundation of stanozolol-induced DNA-damaging results.
The lifetime prevalence of anabolic androgenic
steroids (AAS) use in the Usa is over 1%. Current reports have advised AAS can simply be obtained
over the Web without a prescription, but this has been poorly studied.
This research focused on figuring out the provision and ease of purchase for AAS,
testosterone, and different non-AAS therapies on the Web from the
attitude of a typical consumer. A Google search was
carried out and the top-ranking sites offering AAS for sale
had been individually evaluated for number of AAS supplied, the
buying process, and extra consumer data to support AAS use.
The present outcomes revealed that 87% of websites supplied generally used forms of AAS, injectable
testosterone, and non-AAS hormone therapies.
Importantly, members did not self-report modifications in voice,
highlighting that these adjustments can occur gradually and unnoticed.
A case report covering the transition of a female-to-male transgender receiving 200 mg testosterone enanthate bimonthly described a reduction in imply frequency, and lowering
and contraction of pitch range inside 3–4 months of therapy (222).
Amongst AAS customers there is the idea that AAS might cause gynecomastia via various pathways, similar
to increased progestin action at the mammary glands or elevated prolactin ranges.
While gynecomastia can develop in sufferers with hyperprolactinemia, the
situation arises secondary to the gonadotropin suppression prolactin could cause (203).
Despite the shortage of any proof and even theoretical foundation for
this apply, some AAS users self-medicate with dopamine
agonists corresponding to bromocriptine and cabergoline to lower
their assumed increased prolactin levels and treat their ‘prolactin-induced’ gynecomastia.
These results additionally happen in neuronal culture preparations, in which androgens cut back Aβ levels and its toxicity.
T supplementation (0.2–1.0 μM) of murine N2a neuroblastoma cells
or major cortical neuronal cultures increases manufacturing of the soluble amyloid precursor protein-α (sAPPα), a nonamyloidogenic (α-secretase) enzyme product, and decreases Aβ launch (Gouras et al., 2000).
Low-dose T (10 nM) additionally will increase sAPPα manufacturing in hypothalamic GT1–7 cells (Goodenough et al., 2000) and lowers Aβ42 ranges
in hippocampal neurons (Ma and Liu, 2015). Addition of as
a lot as 100 nM T or DHT to hippocampal neuronal cultures attenuates toxicity of a shortened Aβ fragment (Aβ25–35) (Pike,
2001).
The evidence around whether anabolic steroids can significantly enhance athletic performance is
limited 8. However usually talking, there has been some analysis which has shown that people who
use anabolic steroids will experience an increase in muscle
energy 9. Bhasin et al. 50 demonstrated that 12
weeks of testosterone at a dosage of 10 to 12 instances the normal every day manufacturing price considerably increased strength in younger skilled males and that the effects of testosterone and exercise had been additive.
There is a dosage-dependent effect of anabolic steroids on muscle mass and power 65, sixty six.
Given the wide range of oxidative stress biomarkers altered by AAS (Table 1),
broad spectrum antioxidants corresponding to Nrf2 activators could also be especially beneficial
in supraphysiologic-dose AAS customers and in other groups at risk for growing AD/ADRD.
In non-AD fashions, sulforaphane inhibits GSK3β exercise (Wang et al.,
2016) and will increase AQP4 expression (Zhao et al., 2005).
Thus, Nrf2 activators, via multiple mechanisms, might
slow or stop the development of AD/ADRD.
This structural modification tremendously increases oral bioavailability, although it comes with hepatotoxicity
(11). Eight of the ten links retrieved by looking Google
for “buy steroids” met the inclusion and exclusion standards and have been evaluated for content (Table 1).
The two excluded links have been for a YouTube video and steroid consumer data site (steroid.com).
For the eight evaluated sites, seven of eight (87%) offered injectable testosterone preparations
including enanthate, cypionate, and propionate, whereas no web site offered
non-injectable preparations. Eighty-seven percent
of websites provided probably the most generally abused synthetic AAS including Dianabol,
Deca-Durabolin, Anadrol, Masteron, and Winstrol
(Table 2). Eighty-seven percent of sites offered a quantity of non-AAS hormones commonly together with human growth hormone, insulin-like progress issue, thyroid hormone, and levothyroxine.
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