渋谷スクランブル交差点でバスと歩行者の事故　スマホはやめましょう

2024年6月7日

渋谷スクランブル交差点でバスと歩行者の事故。ながらスマホはやめましょう。
pic.twitter.com/nSFLvoyJAb

— ショウ (@syounokintore) June 5, 2024

ながらスマホ＋イヤホンでしょうね。
これじゃバスが可哀想🥺

— カイくん🚕💨✨ (@qrrqgdL6moFMGOK) June 5, 2024

これでも車両側に過失ついてまうんやろ。当たってきた歩行者が無茶な補償求めてきたら、この映像証拠で徹底的に争った方がええでバス会社はん☝️

— ながP (@neoplan_1988) June 5, 2024

当たり屋ですか？

— はっち⊿ (@hatch_oyaji) June 5, 2024

バスの運転手は右側のカート集団に気を取られたかもしれませんね。
しかし歩行者の自己責任の割合が大きいように思います。

— ヒロ@TKG (@5wDkirKC7pNjlAZ) June 5, 2024

一般ニュース解説

改正案の実効性巡る声に首相反論 2024年6月6日 https://t.co/9ScD7jd34H

欧米住みの日本人の約半数が孤独を感じているらしい。外から日本をこき下ろしているあの人もあの人もさみしいんだよ。優しくしてやってくれ。

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Anavar side effect prevention guideより:
2025年11月1日 2:39 PM
If you are taking steroids to enhance your power and muscle mass, it’s crucial for you to be aware of the health risks you’re taking – both brief term and long term.
There are some reliable medical makes use of for anabolic steroids,
including the remedy of anemia and to reverse protein loss in sufferers who’ve extended immobilization following extreme sickness, trauma,
or surgery. Anabolic steroids are also used for urge for
food stimulation and upkeep of muscle mass in patients with ailments such as most cancers and AIDS.
A latest systematic review and meta-analysis revealed that long-term AASs use results
in prolonged hypogonadotropic hypogonadism in both sexes.
In almost all research included within the meta-analysis,
there were decreased serum LH and FSH levels throughout AASs use [40].
AASs suppress gonadotropin release from the pituitary gland by a unfavorable feedback mechanism, both immediately on the pituitary gland or
indirectly by suppressing the hypothalamic GnRH release.
This leads to a down-regulation of each gonadotropins and a decreased secretion of endogenous steroids [36–40].
As such, it seems cheap to conclude that an absolute extra of estrogenic action causes the development of gynecomastia during AAS use, regardless
of its relative action in contrast with androgens. It appears applicable to
handle dyslipidemia in (long-term) AAS customers based on current guidelines (151) simply as in some other patient.
Risk estimation utilizing algorithms corresponding to SCORE2 would
possibly underestimate risk as a end result of certain unwanted facet effects of AAS use,
such because the detrimental modifications to cardiac structure and function they
elicit, may act as threat modifiers. Echocardiographic proof of such
adjustments would possibly due to this fact assist in ‘grey zone’ threat estimation situations.
The use of HDL-cholesterol boosting dietary supplements,
similar to niacin, might also result in underestimating danger
when utilizing algorithms based mostly on HDL-cholesterol.
If pharmacological intervention is indicated, statins are the first-line of
treatment to lower LDL-cholesterol.
Due To This Fact, it should not be assumed that an AAS-induced decrease in Lp(a) may
negate the opposite results which are detrimental to cardiovascular health.
Therefore, despite the gaps within the literature, present information permits
the conclusion that AAS abusers are extra prone to infertility
and sexual dysfunction. Though these opposed effects may be transitory in some people,
it is unclear who’s more susceptible to everlasting harmful results, neither is it identified if the prevailing therapy can totally resolve these conditions in the long run. In this context, efforts to prevent
the abusive use of those substances ought to be applied from clinical to public
health levels. Primarily Based on these prior stories of suppression of the HPG axis with testosterone, one would
count on decrease rates of being pregnant in AS customers.
The relatively high fee of preservation is most likely going secondary
to the widespread practice of AS users to incorporate adjunctive therapies along with
testosterone or to incorporate washout durations
between intervals of AS use (cycling). Often, the
first objective is not maintenance of fertility, but to stop antagonistic results of AS withdrawal together
with muscle loss, loss of libido, erectile dysfunction, and impaired temper
(18).
AAS can inhibit the release of gonadotropin-releasing hormone
(GnRH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), that are crucial
for correct reproductive perform. As a end result, the disruption of the HPG axis can lead to impaired sperm manufacturing in males and menstrual irregularities in females, ultimately affecting fertility.
Long-term use of Anavar also can result in liver harm, which
may influence its capacity to metabolize hormones like estrogen and testosterone.
However, by growing the focus of testosterone in the
blood with injections of anabolic steroids, there is a continuous blockage of sperm production, leading to a scenario of azoospermia.
Estradiol particularly is extraordinarily potent at suppressing gonadotropin secretion as, on a molar foundation, it’s estimated to be 200-fold stronger than testosterone in doing so (175).
Consequently, exogenously administered AAS may also exert adverse suggestions, thereby suppressing testicular testosterone production and
spermatogenesis. The time course and elements affecting HPGA restoration after cessation of use are poorly characterized.
In distinction with the opposed impact on LDL- and HDL-cholesterol, AAS appear to
exert a neutral or favorable impact on lipoprotein (a) (Lp(a)).
In some instances, prednisone (a type of corticosteroid), has truly been used as a treatment for infertility.
One study observed that irritation of the male urogenital tract could impair sperm quality parameters and scale back male fertility.
Prednisone treatments might assist reduce inflammation, bettering sperm production and quality.
Lifestyle components play a big position in terms of fertility and sperm enchancment.
And drug use, together with the misuse of steroids, is a
sort of components that may have a big impact. Some initial information relating to the time course of HPGA recovery after
AAS use have recently been revealed (176).
“Extra typically, AAS abuse is a growing public health concern and ongoing research is targeted on both the short-term and the long-term physiological and psychological negative unwanted facet effects.” The drug finasteride contained in medication to prevent male sample
baldness has additionally been shown to impact male fertility.
“Levels within the testicles have to be many, many times greater than the blood level for sperm to be produced usually and also you only get this by natural manufacturing,” says fertility specialist Mr Kevin McEleny, a
consultant urologist at Newcastle Hospitals. Quite A Few other research
using information from men who were taking testosterone for prescribed reasons have confirmed that the mechanism is due to negative feedback,
blocking LH release and stopping the testicles from making
testosterone. You should have common appointments along with your healthcare supplier
when taking an anabolic steroid to assess how nicely it’s working.
For athletes, increasing muscle mass may promote strength, which might enhance
strength-based sports activities performance.
Common steroids, known as corticosteroids, are medications that reduce
inflammation and the activity of your immune system.
See the “Low Testosterone” section of this website for extra info on these medications.
A number of leisure substances, including medication, alcohol and tobacco, can impact your fertility.
These medicines (including Propecia® and Avodart®) are used
to deal with hair loss and prostate enlargement. Their
influence in your fertility is usually gentle and will reverse
once you cease the treatment, however whereas you’re taking
them, it could be harder for you to create a being pregnant.
In female athletes, clitoromegaly and menstrual alterations (delayed menarche, oligomenorrhea,
secondary amenorrhea, dysmenorrhea and anovulation) are the primary side effects reported during AASs
use [40].
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