RT @airi_fact_555: 恨むんなら姉を恨むしかないよね… 小室圭さん、佳子さまご結婚の足枷に… 相手の名家・島津家「小室一家が親戚になるのはNG」 https://t.co/Bko4V6LExl

2024年6月1日

RT @airi_fact_555: 恨むんなら姉を恨むしかないよね…

小室圭さん、佳子さまご結婚の足枷に… 相手の名家・島津家「小室一家が親戚になるのはNG」
https://t.co/Bko4V6LExl

— 銃とバッジを置いていけ＆ニチカン　共同運営アカウントをスタート (@kokosatoh)
Jun 1, 2024

from Twitter https://twitter.com/kokosatoh

June 01, 2024 at 05:10PM
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韓国人「日本人と韓国人はやっぱり同じ行動するんだ」・ | ニチカン！ https://t.co/EKt7Hj7ON1

RT @mokosamurai777: 人工衛星を成層圏まで投げる装置。アメリカ、カリフォルニア州で2014年に設立された宇宙技術開発ベンチャー、SpinLaunch。真空遠心分離機を用いた発射台から「ハンマー投げ」の要領で衛星を投げる仕組み。高度60kmに達したら、飛翔…

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Ipamorelin, Tesamorelin and Sermorelin are three of the most commonly discussed peptides in the field of anti-aging and body composition therapy.
Each of them belongs to a broader class known as growth hormone-releasing
peptides (GHRPs) or analogues that act on the pituitary gland to stimulate endogenous production of growth hormone (GH).
While they share the common goal of enhancing
GH levels, their pharmacodynamics, clinical applications,
dosing schedules and side-effect profiles differ
considerably. Understanding these nuances is essential for clinicians, researchers and individuals seeking to
optimize peptide therapy for fat loss, muscle gain or metabolic health.
—
Tesamorelin vs Ipamorelin: Fat Loss Peptide Therapy Comparison
Mechanism of Action
– Tesamorelin is a synthetic analogue of growth hormone-releasing hormone
(GHRH). It binds to the GHRH receptor on pituitary somatotrophs, triggering
the release of GH and subsequently insulin-like growth factor 1
(IGF-1).
– Ipamorelin belongs to the ghrelin mimetic family. It selectively activates the growth hormone secretagogue receptor
type 2 (GHS-R2) on somatotrophs, leading to GH secretion with minimal stimulation of cortisol
or prolactin.
Clinical Efficacy for Fat Loss
– Tesamorelin has been approved by regulatory authorities for
treating excess abdominal fat in HIV-associated lipodystrophy.
In large clinical trials it produced a 20–25 % reduction in visceral
adipose tissue over six months, accompanied by modest
improvements in insulin sensitivity and lipid profiles.
– Ipamorelin’s evidence base is largely derived from smaller studies and anecdotal
reports. When combined with resistance training or caloric restriction, users
often report decreases in subcutaneous fat and improvements in lean body mass.
However, the magnitude of visceral fat reduction appears less
pronounced than that seen with Tesamorelin.
Dosing Regimens
– Tesamorelin is typically administered as a 1 mg subcutaneous injection once daily.
The dose remains constant over the course of therapy; adjustments are rarely needed
once therapeutic targets are achieved.
– Ipamorelin dosing varies widely: common protocols
use 200–300 µg per day, split into two or three injections.
Some practitioners titrate upward to 600–800 µg
based on response and tolerance.
Side-Effect Profile
– Tesamorelin’s side effects are largely dose-dependent and include edema, arthralgia, transient glucose intolerance, and injection site reactions.
Long-term safety data from HIV patients indicate no significant
increase in cancer risk over five years of therapy.
– Ipamorelin is generally well tolerated; reported adverse events include mild injection site
discomfort, transient headache, or a sense of fullness. Because it has
minimal effect on cortisol and prolactin, it rarely causes the water
retention or mood changes sometimes seen with other
GHRPs.
Practical Considerations for Bodybuilders
– Tesamorelin’s once-daily regimen simplifies adherence but may be costlier
due to its patented status.
– Ipamorelin offers flexibility in dosing frequency
and can be paired with anabolic steroids or protein supplementation to maximize muscle hypertrophy while still encouraging fat loss.
—
What Are Growth Hormone-Releasing Peptides?
Growth hormone-releasing peptides (GHRPs) are a subset of
synthetic peptides designed to stimulate the pituitary gland’s release of endogenous growth hormone.
They work by mimicking natural signals that regulate GH secretion:
Natural Stimuli: Ghrelin, GHRH, and somatostatin are key hormones that either promote or inhibit GH
release.
Synthetic Modulators: Peptides such as Sermorelin (a truncated form of GHRH), Ipamorelin,
and Tesamorelin have been engineered to enhance
potency, stability, or receptor selectivity.
The benefits of using GHRPs include:
Physiological GH Release – Unlike exogenous GH injections, GHRPs trigger the body’s own production pathways, maintaining a more natural
pulsatile release pattern.
Reduced Side Effects – Because the hormones act through specific receptors and do not saturate downstream signaling
cascades, they often have fewer adverse events such as water retention or insulin resistance.
Versatility in Clinical Use – GHRPs are employed for growth hormone deficiency, cachexia, sarcopenia,
lipodystrophy, and even athletic performance enhancement.
Key Takeaways
Tesamorelin is a GHRH analogue that has proven efficacy in reducing visceral adipose tissue, particularly in HIV-associated lipodystrophy.
Its once-daily dosing simplifies use but may come with higher costs and a broader side-effect spectrum.
Ipamorelin, as a ghrelin mimetic, offers targeted GH release with minimal impact on cortisol or prolactin. It is highly adaptable for bodybuilding protocols aimed at fat loss and
muscle gain, though its visceral fat reduction effect is modest compared to Tesamorelin.
Sermorelin remains the classic GHRH analogue used mainly in diagnostic settings and for mild GH deficiency; it is less potent than Tesamorelin but has
a long track record of safety.
All three peptides act by stimulating endogenous GH production,
preserving physiological release patterns and generally producing fewer side effects than direct GH administration.
The choice between them should be guided by the specific therapeutic goal (visceral fat loss vs muscle hypertrophy),
budget constraints, dosing convenience, and tolerance to potential adverse events.
By carefully matching peptide properties with individual
objectives, clinicians and users can harness the benefits of GHRPs while minimizing risks.
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However, if someone suspects you’re taking steroids after you speak openly about your use, it’s possible for
them to order a steroid check specifically so that you simply can take.
Speaking abrasively about steroid use in such environments isn’t widespread, though,
as people generally don’t wish to get caught. You don’t need to situation your body
to need mega doses of Anadrol to find a way to make additional gains, which may be the case if somebody
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the price of an oral cycle may effectively lower, as customers
will be capable of take fewer tablets for a similar degree of results.
There was a study that measured whether or
not grapefruit significantly increased the absorption and bioavailability of the intercourse
steroids estradiol and progesterone. Each are fast-acting; nonetheless, Anadrol 50 is an oral, and trenbolone is an injectable.
However when taking any hepatotoxic drug, risks are inconceivable to
get rid of totally. Regular bloodwork monitoring liver enzymes like AST and ALT is smart to assess for indicators of liver
duress during oral steroid cycles. This stands
in stark distinction to the quick spike provided by oral steroids, followed by an equally
fast crash as the medication are metabolized and excreted within hours.
Whereas oral steroids have to be structurally modified on the seventeenth carbon position to guarantee that liver enzymes to be prevented,
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appearing injectables.
It’s used for activity that involves fast bursts of movement, corresponding to weightlifting or sprinting.
However there isn’t any proof that creatine helps you do higher at sports that
make you breathe at a better rate and raise your heart rate, referred to as aerobic sports.
It is essential to do your due diligence earlier than deciding to ingest body-altering
medication. Oxidative stress attributable to steroid metabolism
can contribute to liver toxicity by damaging liver cells.
DHT generally is also lots stronger than Testosterone, and supposedly
also has a stronger binding affinity 5 occasions
stronger than a traditional oral Testosterone steroid.
Some of those side effects may not go away, even should you
stop taking it. People taking oxandrolone may have an elevated threat of
bleeding or bruising. You could additionally be at
larger threat in case you are additionally taking a blood thinner corresponding to
warfarin. Tell your well being care provider should you notice any changes
in how simply you bruise or bleed. Liver injury, also known as hepatotoxicity, can occur when taking oxandrolone.
In uncommon circumstances, some individuals have
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the next symptoms of liver injury.
However, additionally it is an efficient chopping steroid, serving to
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The early studies on steroids clearly confirmed that anabolic steroids provided no athletic benefit in any way,
but in retrospect can be mentioned to have a number of design flaws.
Another reason why Anadrol is female-friendly is due to its low affinity
when binding to SHBG (17). High ranges of intercourse
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be free or unbound. To scale back the danger of harm, bodybuilders can lift lighter weights and perform extra
repetitions. This won’t reduce muscle gains, as we have discovered lighter weights to be just as efficient
for building hypertrophy as heavy weights. Anecdotally,
we discover that 18 lbs of lean muscle is common for a first-time 6-week cycle of Anadrol.
Anadrol is kind of probably the best steroid by
method of weight achieve and rising muscle hypertrophy.
The weight we see gained on Anadrol is typically comprised of muscle and water retention.
Nonetheless, it remains to be decided whether or not therapeutic phlebotomy affects scientific
endpoints corresponding to MACE and VTE or solely ‘treats’ a laboratory abnormality.
The stimulatory effect on erythropoiesis is dose-dependent – a minimum of past 300 mg testosterone enanthate weekly – and
is more pronounced in older men (42). It takes several months of
testosterone treatment earlier than hematocrit stabilizes, with one (uncontrolled) trial reporting a
steady improve in hematocrit up to 12 months in older men receiving testosterone
(43). Treating healthy young males with the 5α-reductase inhibitors finasteride
and dutasteride for one yr had no effect on hemoglobin levels
(44). Likewise, dutasteride had no effect on hemoglobin ranges in contrast with placebo when used in conjunction with graded doses of testosterone
enanthate as much as 600 mg weekly (23).
Orally ingested AAS are rapidly absorbed in the gastrointestinal (GI) tract, with serum concentrations peaking 1–2 hours after ingestion of methyltestosterone
(8). With Out structural modification to resist first-pass metabolism, a big fraction of the absorbed AAS will be metabolized before leaving the liver and re-entering the circulation. For instance, after oral administration of 25 mg
testosterone, lower than 1 mg (4%) turns into systemically
out there (9). The oral bioavailability of AAS
can be increased by making the father or mother molecule more
lipid-soluble by the esterification process described in the earlier paragraph.
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